Featured Publications

1. Tian Hua, Xiaoting Li, Lijie Wu, Laura M. Bohn, Alexandros Makriyannis, Zhi-Jie Liu, Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures, Cell (2020)

2. X. Li, T. Hua, K. Vemuri, S. J. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, GW. Han, M. Iyer, R. Cinar, N. Coffey, J. Wang, M., Wu, V. Katritch, S. Zhao, G. Kunos, L. Bohn, A. Makriyannis, R Stevens. Liu ZJ* (2019) Crystal Structure of the Human Cannabinoid Receptor CB2. Cell, 176(3): 459-467 e413

3. Peng Y, J. D. McCorvy, K. Harpsoe, K. Lansu, S. Yuan, P. Popov, L. Qu, M. Pu, T. Che, L. F.   Nikolajsen, X. P. Huang, Y. Wu, L. Shen, W. E. Bjorn-Yoshimoto, K. Ding, D. Wacker, G. W. Han, J. Cheng, V. Katritch, A. A. Jensen, M. A. Hanson, S. Zhao, D. E. Gloriam, B. L. Roth, R. C. Stevens and Z. J. Liu (2018). 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell, 172(4), 719-730.

4. T. Hua, K. Vemuri, S. Nikas, R. Laprairie, Y. Wu, L. Qu, M. Pu, A. Korde, S. Jiang, J.H. Ho, GW. Han, D. Ding, X. Li, H. Liu, S. M. Hanson, S. Zhao*, L. Bohn*, A. Makriyannis*, R Stevens. Liu ZJ* (2017) Crystal Structure of agonist-bound Human Cannabinoid Receptor CB1. Nature, 547 (7664): 468-471

5. Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu Z.J*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 546(7657):312-315.

6. T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn*, A. Makriyannis*, R Stevens*. ZJ. Liu* (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762.

More Publications

7. X., Song, H., Shan, Y., Zhu, S., Hu, L., Xue, Y., Chen, W., Ding, T., Niu, J., Gu, S., Ouyang*, Q., Shen*, Z-J Liu* (2019) Self-capping of nucleoprotein filaments protects Newcastle Disease Virus genome. eLIFE, 8:e45057.
8. J. Li, J. Rodriguez, F. Niu, M. Pu, J. Wang, L.Hung, Q. Shao, Y.Zhu, W. Ding, Y.Liu, Y. Da, Z. Yao, J. Yang, Y. Zhao, G. Wei, G. Cheng, ZJ. Liu, S. Ouyang (2016) Structural basis for DNA recognition by STAT6. PNAS, 113(46), 13015-130-20.
9. Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6:7300.
10. Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58
11. Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9.
12. Ru, H., Ni, X. , Zhao, L. , Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu, Z. J*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Research, 23(6):855-8.
13. OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu, Z. J*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086.
14. Wu, D., Li, Y., Song, GJ, Zhang, R., Joachimiak, A., Shaw, N., & Liu, Z. J*. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, 69(18), 7294-301. (Cover)
15. Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., Liu, Z. J*., Wang, B. C. & Rao, Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, 14(8), 779-84.
16. Shaw, N., Cheng, C., and Liu, Z. J*, (2007) Procedure for reductive methylation of protein to improve crystallizability. Nature Protocols DOI: 10.1038/nprot.2007.287
17. Liu, Z.J., Stepanyuk, G.A., Vysotski, E.S., Lee, J., Markova, S.V., Malikova, N.P., and Wang, B.C. (2006). Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. Proc Natl Acad Sci 103, 2570-2575.
18. J. Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang*, Z. J. Liu*, W. Han*, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented "EF-Hand-Like" Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109.